Regioselective alkylation of the lower rim of p-tert-butylthiacalix[4]arene with N-(p-nitrophenyl)-α-bromoacetamide

Author: Stoikov Ivan  

Publisher: Taylor & Francis Ltd

ISSN: 1061-0278

Source: Supramolecular Chemistry, Vol.21, Iss.7, 2009-10, pp. : 564-571

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Abstract

The preparation of partially substituted thiacalix[4]arenes 2-6 has been accomplished by conducting the reaction of the thiacalixarene 1 with N-(p-nitrophenyl)-α-bromoacetamide in acetone or acetonitrile in the presence of M2CO3 (M = Na, K and Cs). The influence of the reaction conditions (temperature, time, solvent, ratio of the reagents and the nature of the alkali metal carbonate) on regio- and stereoselectivity of this reaction is described.

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