Five furostanol saponins from fruits of Tribulus terrestris and their cytotoxic activities

ISSN： 1478-6419

Source： Natural Product Research, Vol.23, Iss.15, 2009-10, pp. : 1436-1444

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Abstract

Two new furostanol saponins, terrestroside A, 3-O-{β-D-xylopyranosyl-(1 → 3)-[β-D-xylopyranosyl(1 → 2)]-β-D-glucopyranosyl(1 → 4)-[α-L-rhamnopyranosyl(1 → 2)]-β-D-galactopyranosy}-26-O-β-D-glucopyranosyl-L-5a-furost-20(22)-en-(25R)-3β,26-diol (1) and terrestroside B, 3-O-{β-D-xylopyran-osyl(1 → 3)-[β-D-xylopyranosyl(1 → 2)]-β-D-glucopyranosyl(1 → 4)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-galactopyranosy}-26-O-β-D-glucopyranosyl-5a-furostan-12-one-(25R)-22-methoxy-3β,26-diol (2), together with three known compounds, chloromaloside E (3), terrestrinin B (4) and terrestroneoside A (5) were isolated from the dry fruits of Tribulus terrestris. Furthermore, the inhibitory effects of the compounds on tumour cells were evaluated, and compounds 1-5 showed potential anti-tumour activity.