Author: De Maio Nicola
Publisher: Oxford University Press
ISSN: 0737-4038
Source: Molecular Biology and Evolution, Vol.30, Iss.3, 2013-03, pp. : 725-736
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Abstract
Empirical codon models (ECMs) estimated from a large number of globular protein families outperformed mechanistic codon models in their description of the general process of protein evolution. Among other factors, ECMs implicitly model the influence of amino acid properties and multiple nucleotide substitutions (MNS). However, the estimation of ECMs requires large quantities of data, and until recently, only few suitable data sets were available. Here, we take advantage of several new
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