Update on recent prognostic markers in adenocarcinoma

Author： Lin Jules   Beer David G  

Publisher： Future Medicine

ISSN： 1758-1966

Source： Lung Cancer Management, Vol.2, Iss.2, 2013-04, pp. : 141-152

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Abstract

SUMMARY Biomarkers have evolved from individual markers to gene signatures validated in multi-institutional studies and independent datasets. Multiple gene signatures have been associated with survival, as well as defining outcome following specific adjuvant chemotherapy. The heterogeneity of lung cancer has necessitated the incorporation of multiple genes in mRNA signatures. The use of plasma miRNA profiles in the diagnosis or prognosis of early-stage lung carcinoma also appears promising. However, challenges remain, with questions regarding reproducibility, standardized techniques, cost and differences between gene signatures. Before they can be widely adopted, molecular profiles must be validated in large, prospective trials evaluating the specific patient population for which the profiles are to be utilized.

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