Author： Khan F.A.
Publisher： Springer Publishing Company
ISSN： 0049-4747
Source： Tropical Animal Health and Production, Vol.31, Iss.4, 1999-08, pp. : 193-204
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Abstract
The strategic use of single therapeutic doses of closantel, tetramisole or sustained low-level administration of albendazole in feed pellets in controlling naturally acquired parasitic gastroenteritis in sheep was investigated on a farm in semi-arid Rajasthan, India. A total of 303 5- to 6-month-old sheep were divided into three groups. Two groups were dosed with single therapeutic doses of closantel and tetramisole and the third group was given a low-level medication with albendazole through feed pellets for 30 days. Faecal egg counts revealed significantly lower counts (p<0.001) in="" the="" group="" treated="" with="" closantel="" compared="" to="" the="" other="" two="" groups.="" the="" faecal="" egg="" counts="" in="" the="" group="" receiving="" sustained="" low-level="" albendazole="" rose="" after="" withdrawal="" of="" the="" medication="" but="" remained="" significantly="" lower="" than="" those="" in="" the="" group="" treated="" with="" tetramisole="" up="" to="" 7="" weeks="" after="" treatment=""><0.05). on="" the="" other="" hand,="" in="" the="" group="" treated="" with="" tetramisole,="" the="" mean="" faecal="" egg="" count="" rose="" from="" 3="" weeks="" after="" treatment="" and="" remained="" continuously="" higher="" than="" those="" in="" any="" other="" group="" up="" to="" 12="" weeks="" after="" treatment.="" the="" closantel-treated="" group="" gained="" more="" body="" weight="" but="" the="" first="" six-monthly="" greasy="" fleece="" yield="" was="" greater="" in="" the="" group="" treated="" with="" medicated="" pellets.="" during="" the="" first="" 3="" months="" of="" the="" experiment,="" three="" animals="" in="" the="" group="" treated="" with="" tetramisole="" died="" of="" parasitic="" gastroenteritis.="" following="" sustained="" low-level="" administration="" of="" albendazole="" in="" feed="" pellets,="" the="" plasma="" disposition="" curve="" of="" both="" the="" sulphoxide="" and="" sulphone="" metabolites="" reached="" its="" plateau="" level="" by="" day="" 5="" and="" remained="" almost="" constant="" thereafter.="" the="" comparative="" cost-effectiveness="" of="" the="" three="" treatment="" regimes="" during="" the="" first="" 3="" months="" of="" treatment="" was="" best="" for="" the="" group="" treated="" with="" closantel="" followed="" by="" the="" group="" treated="" with="" medicated="" feed="" pellets.="">
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