Author： Abd El-Aty A.M. Goudah A.
Publisher： Springer Publishing Company
ISSN： 0165-7380
Source： Veterinary Research Communications, Vol.26, Iss.7, 2002-10, pp. : 553-561
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Abstract
The aim of this study was to elucidate some of the pharmacokinetic parameters of pefloxacin in lactating goats (n = 5) following intravenous (i.v.) or intramuscular (i.m.) injections of 10 mg/kg bw. Serially obtained serum, milk and urine samples were collected at precise time intervals, and the drug concentrations were assayed using a microbiological assay. A two-compartment open model best described the decrease of pefloxacin concentration in the serum after intravenous administration. The maximum serum concentration (Cp0) was 8.4±0.48 μg/ml; elimination half-life (t1/2β) was 1.6±0.3 h; total body clearance (Cltot) was 3.6±0.3 L/kg/h; steady-state volume of distribution (Vdss) was 5.14±0.21 L/kg; and the area under the curve (AUC) was 2.78±0.22 μg.ml/h. Pefloxacin was absorbed rapidly after i.m. injection with an absorption half-life (t1/2ab) of 0.32±0.02 h. The peak serum concentration (Cmax) of 0.86±0.08 μg/ml was attained at 0.75 h (Tmax). The absolute bioavailability after i.m. administration was 70.63±1.13% and the serum protein-bound fraction ranged from 7.2% to 14.3%, with an average value of 9.8±1.6%. Penetration of pefloxacin from the blood into the milk was rapid and extensive, and the pefloxacin concentration in milk exceeded that in serum from 1 h after administration. The drug was detected in milk and urine for 10 and 72 h, respectively; no samples were taken after 72 h.
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