Implications of Fungicidal Effects of Benzimidazole Compounds on Duddingtonia flagrans in Integrated Nematode Parasite Management in Livestock

Author： Sanyal P.K.

Publisher： Springer Publishing Company

ISSN： 0165-7380

Source： Veterinary Research Communications, Vol.28, Iss.5, 2004-07, pp. : 375-385

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Abstract

An in vitro trial with carbendazim fungicide on the growth profile of the predatory fungus Duddingtonia flagrans was undertaken and in vivo trials in sheep and buffaloes, fed on chlamydospores of D. flagrans and administered albendazole anthelmintic, were conducted. Although no growth inhibition was detected at a carbendazim concentration of 0.05 ppm, growth inhibition was recorded of 50% and above at concentrations of 0.25 and 1.00 ppm (p<0.001) and="" of="" around="" 90%="" at="" concentrations="" of="" 2.00="" to="" 5.00="" ppm="">p<0.0001). scanty="" recovery="" of="" the="" fungus="" was="" made="" from="" faecal="" culture="" 48="" h="" following="" a="" single="" dose="" of="" albendazole="" both="" in="" sheep="" and="" buffaloes.="" however,="" profuse="" fungal="" recovery="" was="" made="" from="" 96="" h="" post="" dosing="" onwards.="" when="" the="" drug="" was="" used="" as="" an="" intraruminal="" slow-release="" capsule,="" no="" faecal="" fungal="" recovery="" could="" be="" made="" from="" day="" 3="" after="" administration="" of="" the="" capsule,="" when="" the="" albendazole="" sulphoxide="" concentration="" was="" around="" 1.0="" μg/ml.="" however,="" profuse="" and="" scanty="" fungal="" recovery="" could="" be="" made="" on="" days="" 1="" and="" 2,="" respectively,="" after="" administration="" of="" the="" capsule,="" when="" the="" plasma="" albendazole="" sulphoxide="" concentration="" was="" around="" 0.4="" and="" 0.9="" μg/ml,="" respectively.="" the="" implications="" for="" use="" of="" a="" combination="" of="" anthelmintics="" and="" biological="" control="" in="" sustainable="" parasite="" control="" programmes="" are="" discussed.="">