Author： Qi Gao-fei Yang Zheng-yin Wang Bao-dui
Publisher： Springer Publishing Company
ISSN： 0340-4285
Source： Transition Metal Chemistry, Vol.32, Iss.2, 2007-03, pp. : 233-239
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Abstract
A new ligand, 2-carboxybenzaldehyde-(4’-hydroxy)benzoylhydrazone(H2L) and its ZnII and NiII complexes have been synthesized and characterized on the basis of elemental analyses, molar conductivities, 1H-NMR, IR spectra and thermal analyses. In addition, DNA-binding properties of these two metal complexes were investigated using spectrometric titrations, ethidium bromide displacement experiments, and viscosity measurements. The results show that the two complexes, especially the NiII complex, strongly bind with calf-thymus DNA, presumably via an intercalation mechanism. The intrinsic binding constants of the ZnII and NiII complexes with DNA are 2.46 × 105 and 7.94 × 105 M −1, respectively.
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