On the Use of Post-Transcriptional Processing Elements in Transgenes

Author: Whitelaw C.B.A.  

Publisher: Springer Publishing Company

ISSN: 0962-8819

Source: Transgenic Research, Vol.13, Iss.1, 2004-02, pp. : 75-79

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Abstract

RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.

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