Author： van Gestel S.
Publisher： Springer Publishing Company
ISSN： 0001-8244
Source： Behavior Genetics, Vol.30, Iss.2, 2000-03, pp. : 141-146
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus (QTL) (??^2 = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.
Related content
By Rosenberg Shai Templeton Alan Feigin Paul Lancet Doron Beckmann Jacques Selig Sara Hamer Dean Skorecki Karl
Human Genetics, Vol. 120, Iss. 4, 2006-11 ,pp. :
Access to resources
Recommend
Testing Quantitative Traits for Association and Linkage in the Presence or Absence of Parental Data
Human Heredity, Vol. 51, Iss. 4, 2001-03 ,pp. :