Author： Foroud T.
Publisher： Springer Publishing Company
ISSN： 0001-8244
Source： Behavior Genetics, Vol.32, Iss.1, 2002-01, pp. : 57-67
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The inbred preferring (iP) and nonpreferring (iNP) rat strains were derived from the selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) lines. Previously, 381 iP × iNP F2 progeny were generated to identify quantitative trait loci (QTLs) influencing alcohol consumption and preference. Saccharin consumption (ml/48 h) and saccharin intake (ml/kg/day) were also measured in the F2 sample and were significantly correlated with both alcohol consumption and preference (all r ≥ .20, p < .0001),="" suggesting="" that="" there="" might="" be="" some="" qtls="" influencing="" both="" saccharin="" and="" alcohol="" phenotypes.="" we="" have="" performed="" a="" genome="" screen="" using="" f2="" animals="" with="" extreme="" saccharin="" or="" alcohol="" consumption="" to="" identify="" qtls="" contributing="" to="" saccharin-related="" phenotypes.="" lod="" scores="" greater="" than="" 2.0="" were="" found="" on="" chromosomes="" 3,="" 16="" and="" 18="" in="" this="" sample.="" additional="" genotyping="" was="" performed="" in="" these="" regions="" in="" the="" full="" sample="" of="" 381="" f2="" progeny="" to="" further="" characterize="" these="" putative="" qtls.="" on="" chromosome="" 3,="" the="" maximum="" lod="" score="" in="" the="" full="" sample="" was="" 2.7="" with="" saccharin="" consumption.="" this="" qtl="" appears="" to="" overlap="" with="" a="" qtl="" identified="" for="" alcohol="" consumption="" in="" the="" ip="" and="" inp="" lines="" and="" has="" pleiotropic="" effects="" on="" both="" phenotypes.="" interestingly,="" this="" region="" of="" rat="" chromosome="" 3="" is="" syntenic="" with="" mouse="" chromosome="" 2,="" where="" a="" qtl="" influencing="" alcohol="" preference="" has="" been="" previously="" reported.="" the="" qtl="" on="" chromosome="" 16="" has="" a="" maximum="" lod="" score="" of="" 4.0="" with="" saccharin="" intake="" and="" 2.6="" with="" saccharin="" consumption.="" the="" qtl="" on="" chromosome="" 18="" has="" a="" maximum="" lod="" score="" of="" 2.7="" with="" saccharin="" consumption.="" taken="" together,="" these="" data="" provide="" the="" first="" results="" of="" a="" genome="" screen="" for="" qtls="" contributing="" to="" saccharin="" phenotypes="" in="" the="" rat.="">
Related content
By Carr Lucinda Habegger Kirk Spence John Liu Lixiang Lumeng Lawrence Foroud Tatiana
Behavior Genetics, Vol. 36, Iss. 2, 2006-03 ,pp. :
Access to resources
Recommend
By Bice Paula Foroud Tatiana Carr Lucinda Zhang Lili Liu Lixiang Grahame Nicholas Lumeng Lawrence Li Ting-Kai Belknap John
Behavior Genetics, Vol. 36, Iss. 2, 2006-03 ,pp. :
Behavior Genetics, Vol. 32, Iss. 5, 2002-01 ,pp. :