Author： Radkov O.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.154, Iss.3, 2013-01, pp. : 354-356
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Abstract
We studied phenotypes of the circulating renin-angiotensin-aldosterone system and circadian BP during preeclampsia depending on polymorphism of angiotensinogen gene M235T.</i> The TT</i> genotype or T</i> allele of angiotensinogen M235T</i> gene polymorphism is associated with the risk of preeclampsia. Plasma renin activity signifi cantly decreases under conditions of preeclampsia. The TT</i> genotype of angiotensin M235T</i> gene polymorphism is associated with highest renin activity and highest 24-h diastolic BP in comparison with MT</i> and MM</i> genotypes in patients with preeclampsia. Plasma aldosterone level is lower in patients with preeclampsia, but this is not related to angiotensinogen M235T</i> gene polymorphism.
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