Author： Son K-H. Hong S-H. Kwon Y-K. Bae K-S. Kim Y-K. Kwon B-M. Kim S-U. Bok S-H.
Publisher： Springer Publishing Company
ISSN： 0141-5492
Source： Biotechnology Letters, Vol.20, Iss.2, 1998-02, pp. : 149-151
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Abstract
Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.
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