Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus

ISSN： 0144-8463

Source： Bioscience Reports, Vol.26, Iss.1, 2006-02, pp. : 1-6

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Abstract

Multiple blood cell types and metabolic pathways involved in the modulation of platelet reactivity were investigated in streptozotocin-induced diabetic rats treated with garlic oil. Platelet counts of diabetic rats treated with garlic oil were significantly (P</i><0.01) reduced="" as="" compared="" to="" diabetic="" control="" rats.="" garlic="" oil="" also="" increased="" the="" leucocyte="" counts="" of="" diabetic="" rats="" as="" compared="" to="" diabetic="" control="" rats.="" the="" significant=""></0.01)>P</i><0.001) decreases="" by="" garlic="" oil="" of="" plasma="" concentration="" factors,="" v,="" vii,="" viii:="" c,="" ix="" and="" x="" in="" diabetic="" rats="" may="" be="" interpreted="" to="" mean="" that="" there="" was="" a="" modulation="" of="" factor="" vii="" similar="" to="" that="" brought="" about="" by="" thrombin="" on="" factors="" v="" and="" viii:="" c.="" this="" reversal="" of="" hypercoagulation="" through="" integrated="" biochemical="" reaction="" is="" suggestive="" of="" multicellular="" modulation="" of="" platelet="" reactivity,="" erythrocytes="" and="" neutrophils="" and="" the="" functional="" interactions="" between="" plasma="" coagulation="" factors="" and="" platelet="" cofactors.=""></0.001)>