The impact of an aromatase inhibitor on body composition and gonadal hormone levels in women with breast cancer

ISSN： 0167-6806

Source： Breast Cancer Research and Treatment, Vol.125, Iss.2, 2011-01, pp. : 441-446

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Abstract

Aromatase inhibitors (AIs) have become the standard adjuvant therapy of postmenopausal breast cancer survivors. AIs induce a reduction of bioavailable estrogens by inhibiting aromatase, which would be expected to induce alterations in body composition, more extensive than induced by menopause. The objectives are to examine the impact of AIs on (1) DXA-scan derived body composition and (2) gonadal hormone levels. This is a sub-analysis of a 2-year double-blind, placebo-controlled, randomized trial of 82 women with nonmetastatic breast cancer, newly menopausal following chemotherapy, who were randomized to risedronate (35 mg once weekly) versus placebo, and stratified for their usage of AI versus no AI. Outcomes included DXA-scan derived body composition and gonadal hormone levels. As a group, total body mass increased in women over 24 months. Women on AIs gained a significant amount of lean body mass compared to baseline as well as to no-AI users (P</i> < 0.05). women="" not="" on="" an="" ai="" gained="" total="" body="" fat="" compared="" to="" baseline="" and="" ai="" users=""></ 0.05).>P</i> < 0.05). free="" testosterone="" significantly="" increased="" and="" sex="" hormone="" binding="" globulin="" (shbg)="" significantly="" decreased="" in="" women="" on="" ais="" compared="" to="" no="" ais="" at="" 24 months=""></ 0.05).>P</i> < 0.01) while="" total="" estradiol="" and="" testosterone="" levels="" remained="" stable.="" independent="" of="" ai="" usage,="" chemotherapy-induced="" postmenopausal="" breast="" cancer="" patients="" demonstrated="" an="" increase="" of="" total="" body="" mass.="" ai="" users="" demonstrated="" maintenance="" of="" total="" body="" fat,="" an="" increase="" in="" lean="" body="" mass="" and="" free="" testosterone="" levels,="" and="" a="" decrease="" in="" shbg="" levels="" compared="" to="" no-ai="" users.="" the="" mechanisms="" and="" implications="" of="" these="" changes="" need="" to="" be="" studied="" further.=""></ 0.01)>