Author： Schmitz J.C. Liu J. Lin X. Chen T-m. Yan W. Tai N. Gollerkeri A. Chu E.
Publisher： Springer Publishing Company
ISSN： 0167-7659
Source： Cancer and Metastasis Reviews, Vol.20, Iss.1-2, 2001-03, pp. : 35-43
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Abstract
Cellular drug resistance is one of the principal obstacles to the clinical efficacy of cancer chemotherapy. In this review, we describe the potential role for translational regulation as a novel mechanism for modulating chemosensitivity. The evidence for the translational control of thymidylate synthase, dihydrofolate reductase, and p53 will be presented, as will experimental data showing how disruptions in this important regulatory process can lead to the rapid emergence of cellular drug resistance.
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