Changes in Quantitative Ultrasound in Infants Born at Less than 32 Weeks’ Gestation Over the First 2 Years of Life: Influence of Clinical and Biochemical Changes

Author: McDevitt H.  

Publisher: Springer Publishing Company

ISSN: 0171-967X

Source: Calcified Tissue International, Vol.81, Iss.4, 2007-10, pp. : 263-269

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Abstract

Studies in preterm infants show reduced speed of sound (SOS) as measured by quantitative ultrasound (QUS) during the immediate neonatal period. There is a scarcity of data on SOS changes following hospital discharge. The aim of this study was to assess SOS over the first 2 years in preterm infants. Infants were recruited from a neonatal follow-up clinic. Tibial QUS was performed using the Omnisense 7000P scanner. Thirty-nine infants born at <32 weeks’="" gestation="" had="" a="" single="" sos="" measurement="" (median="" 3,203="" m/second,="" range="" 2,609–3,495)="" which="" correlated="" with="" corrected="" gestational="" age="" (cga)=""></32>r</i> = 0.8, P</i> < 0.005). the="" majority="" of="" measurements="" were="" within="" the="" manufacturer’s="" reference="" range="" for="" term="" infants.="" sos="" standard="" deviation="" score="" (sds)="" in="" infants="" aged="" 0–6="" months="" cga="" demonstrated="" a="" negative="" correlation="" with="" duration="" of="" total="" parenteral="" nutrition=""></ 0.005).>r</i> = 0.7, P</i> < 0.05) and="" a="" positive="" correlation="" with="" serum="" phosphate=""></ 0.05)>r</i> = 0.6, P</i> < 0.05.) two="" groups="" of="" infants="" had="" serial="" measurements:="" eight="" had="" measurements="" performed="" at="" term="" cga="" and="" early="" infancy="" (early)="" and="" seven="" had="" measurements="" in="" later="" infancy="" (late).="" in="" the="" early="" group="" sos="" sds="" increased=""></ 0.05.)>P</i> < 0.005), and="" the="" greatest="" increase="" in="" sos="" over="" time="" occurred="" in="" infants="" with="" the="" lowest="" sos="" at="" term=""></ 0.005),>r</i> = 0.9). In the late group there was no significant change over time. SOS SDS change did not show any correlation to weight SDS change. Catch-up in SOS occurs postterm in most infants by 6 months and is independent of postnatal growth. Infants with the lowest SOS at term have the fastest rate of catch-up. The opportunity for catch-up may be greatest in early infancy.

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