Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis

Author: Manjari K.  

Publisher: Springer Publishing Company

ISSN: 0254-8860

Source: Indian Journal of Gastroenterology, Vol.32, Iss.2, 2013-03, pp. : 103-107

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Abstract

The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP).Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay.The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p</i> < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p</i> = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p</i> < 0.001) were significantly elevated in CP compared to the control group.The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.

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