The effect of metformin treatment to ovarian response in cases with PCOS

ISSN： 0932-0067

Source： Archives of Gynecology and Obstetrics, Vol.269, Iss.2, 2004-01, pp. : 121-124

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Abstract

To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOS patients. Randomized prospective study. Zeynep Kamil Hospital IVF Center. Thirty-two female PCOS patients with clomiphene citrate resistance. Test group A received 2×850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B. Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with ≥16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate. The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group. Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.