Coffee and tea consumption and endometrial cancer risk in a population-based study in New Jersey

ISSN： 0957-5243

Source： Cancer Causes and Control, Vol.21, Iss.9, 2010-09, pp. : 1467-1473

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Abstract

We evaluated the role of tea and coffee and substances added (sugar/honey, creamers, and milk) on endometrial cancer risk in a population-based case–control study in six counties in New Jersey, including 417 cases and 395 controls. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression. There was a moderate inverse association with coffee consumption, with an adjusted OR of 0.65 (95% CI: 0.36–1.17) for women who reported more than two cups/day of coffee compared to none. Tea consumption appeared to increase risk (OR: 1.93; 95% CI: 1.08–3.45), but after including the variables sugar/honey and cream/milk added to tea in the model, the risk estimate was attenuated and no longer statistically significant (OR: 1.77; 95% CI: 0.96–3.28 for those consuming more than one cup/day of tea compared to nonusers). There was a suggestion of a decreased risk associated with green tea, but the confidence interval included one (adjusted OR for one or more cups/week vs. none: 0.75; 95% CI: 0.48–1.18). We found an association with adding sugar/honey to tea, with those adding two or more teaspoons/cup having an OR of 2.66 (95% CI: 1.42–4.98; p</i> for trend <0.01) after="" adjusting="" for="" relevant="" confounders.="" for="" sugar/honey="" added="" to="" coffee="" the="" corresponding="" or="" was="" 1.43="" (95%="" ci:="" 0.81–2.55).="" our="" results="" indicate="" that="" sugars="" and="" milk/cream="" added="" to="" coffee="" and="" tea="" should="" be="" considered="" in="" future="" studies="" evaluating="" coffee="" and="" tea="" and="" endometrial="" cancer="" risk.=""></0.01)>