Author: Rosaria Alba Merendino Giuseppe Di Pasquale Filippo De Luca Laura Di Pasquale Edoardo Ferlazzo Gabriella Martino Maura Carmela Palumbo Fortunato Morabito Sebastiano Gangemi
Publisher: Informa Healthcare
ISSN: 1466-1861
Source: Mediators of Inflammation, Vol.13, Iss.3, 2004-06, pp. : 205-207
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Abstract
M oderate -severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1 in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1 was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.
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