A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

By Pagenstecher Axel   Stahl Sonja   Sure Ulrich   Felbor Ute  

Human Molecular Genetics, Vol. 18, Iss. 5, 2009-03 ,pp. : 911-918

Oxford University Press

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KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations ( CCM1 ) pathogenesis

By Serebriiskii I.G.  

Human Molecular Genetics, Vol. 11, Iss. 4, 2002-02 ,pp. : 389-396

Oxford University Press

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Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations ( CCM1 )

By Sahoo Trilochan   Johnson Eric W.  

Human Molecular Genetics, Vol. 8, Iss. 12, 1999-11 ,pp. : 2325-2333

Oxford University Press

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Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

By Akers Amy L.   Johnson Eric   Steinberg Gary K.   Zabramski Joseph M.   Marchuk Douglas A.  

Human Molecular Genetics, Vol. 18, Iss. 5, 2009-03 ,pp. : 919-930

Oxford University Press

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Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations

By Cunningham Kirk   Uchida Yutaka   O'Donnell Erin   Claudio Estefania   Li Wenling   Soneji Kosha   Wang Hongshan   Mukouyama Yoh-suke   Siebenlist Ulrich  

Human Molecular Genetics, Vol. 20, Iss. 16, 2011-08 ,pp. : 3198-3206

Oxford University Press

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