Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

By Shirendeb Ulziibat P.   Calkins Marcus J.   Manczak Maria   Anekonda Vishwanath   Dufour Brett   McBride Jodi L.   Mao Peizhong   Reddy P. Hemachandra  

Human Molecular Genetics, Vol. 21, Iss. 2, 2012-01 ,pp. : 406-420

Oxford University Press

Access to resources Recommend Favorite

The A 2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitinproteasome system

By Chiang Ming-Chang   Chen Hui-Mei   Lai Hsing-Lin   Chen Hsiao-Wen   Chou Szu-Yi   Chen Chiung-Mei   Tsai Fuu-Jen   Chern Yijuang  

Human Molecular Genetics, Vol. 18, Iss. 16, 2009-08 ,pp. : 2929-2942

Oxford University Press

Access to resources Recommend Favorite

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

By Kuhn Alexandre   Goldstein Darlene R.   Hodges Angela   Strand Andrew D.   Sengstag Thierry   Kooperberg Charles   Becanovic Kristina   Pouladi Mahmoud A.   Sathasivam Kirupa   Cha Jang-Ho J.   Hannan Anthony J.   Hayden Michael R.   Leavitt Blair R.   Dunnett Stephen B.   Ferrante Robert J.   Albin Roger   Shelbourne Peggy   Delorenzi Mauro   Augood Sarah J.   Faull Richard L.M.   Olson James M.   Bates Gillian P.   Jones Lesley   Luthi-Carter Ruth  

Human Molecular Genetics, Vol. 16, Iss. 15, 2007-08 ,pp. : 1845-1861

Oxford University Press

Access to resources Recommend Favorite

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

By Wang Chuan-En   Tydlacka Suzanne   Orr Adam L.   Yang Shang-Hsun   Graham Rona K.   Hayden Michael R.   Li Shihua   Chan Anthony W.S.   Li Xiao-Jiang  

Human Molecular Genetics, Vol. 17, Iss. 17, 2008-09 ,pp. : 2738-2751

Oxford University Press

Access to resources Recommend Favorite

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

By Schilling Gabriele  

Human Molecular Genetics, Vol. 13, Iss. 15, 2004-08 ,pp. : 1599-1610

Oxford University Press

Access to resources Recommend Favorite