Seminal plasma can be a predictive factor for male infertility

ISSN： 1460-2350

Source： Human Reproduction, Vol.11, Iss.6, 1996-06, pp. : 1223-1226

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Abstract

Seminal plasma from ejaculates of 10 healthy, fertile volunteers and 63 infertile males was analysed for superoxide dismutase (SOD) and xanthine oxidase (XO) activities using a chemiluminometer. There was no statistically significant difference in the activity of either enzyme between control and infertile populations (113± 74 IU/ml for SOD and 1.17 ± 0.52 IU/l for XO) in samples from normozoospermic ejaculates. Sperm progressive motility was positively correlated with SOD activity in seminal plasma of corresponding ejaculates (P < 0.05)="" and="" negatively="" with="" xo="" activity="">P < 0.001).="" an="" ‘oxido-sensitive’="" index="" was="" defined="" as="" the="" sod/xo="" ratio="" and="" was="" found="" to="" be="" inversely="" related="" to="" sperm="" progressive="" motility="" samples="">P < 0.01).="" analysing="" this="" index="" among="" all="" tested="" samples="" of="" semen="" including="" those="" with="" pathological="" spermiograms,="" as="" well="" as="" normospermic="" (n)="" samples="" we="" found="" statistically="" significant="" (elevated)="" differences="" in="" oligoasthenoteratospermia="" (oat)="" in="" comparison="" with="" n="">P < 0.05);="" oat="" samples="" were="" also="" significantly="" different="" from="" oligospermic="" (o)="" and="" oligoteratospermic="" (ot)="" samples="">P < 0.05).="" this="" suggests="" that="" the="" ‘oxido-sensitive’="" index="" of="" seminal="" plasma="" may="" be="" a="" simple="" diagnostic="" factor,="" useful="" in="" the="" determination="" of="" male="" infertility.="">