Author： Chen Jack Aduda Vince
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.37, Iss.20, 2007-01, pp. : 3493-3499
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Abstract
A fast and highly convenient procedure for the formation of Fmoc-protected amino aldehydes from the corresponding alcohols using 1.1 equiv. of IBX in the presence of dimethylsulfoxide (DMSO) is discussed. This procedure leads to the clean synthesis of Fmoc-amino aldehydes in excellent yields with less than 1% epimerization and with no chromatography required for purification.
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