Author： Sabitha Gowravaram Bhikshapathi M. Nayak Sambit Yadav J. S.
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.41, Iss.1, 2011-01, pp. : 8-15
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Abstract
A simple and efficient one-pot synthesis of symmetrical 4-amido tetrahydropyrans via the Sakurai-Prins-Ritter reaction sequence using molecular iodine as catalyst from an aldehyde and allyltrimethylsilane in acetonitrile is described. This new method has the advantage of good to excellent yields (60-98%) and short reaction times (20-150 min) at ambient temperature with high diastereoselectivity.
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