Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds

By Huang Liyue   Chen April   Roberts John   Janosky Brett   Be Xuhai   Berry Loren   Lin Min-Hwa Jasmine  

Xenobiotica, Vol. 42, Iss. 9, 2012-09 ,pp. : 830-840

Informa Healthcare

Access to resources Recommend Favorite

Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance

By Foster Joanne A.   Houston J. Brian   Hallifax David  

Xenobiotica, Vol. 41, Iss. 2, 2011-02 ,pp. : 124-136

Informa Healthcare

Access to resources Recommend Favorite

Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes

By Sohlenius-Sternbeck Anna-Karin   Jones Christopher   Ferguson Douglas   Middleton Brian J.   Projean Denis   Floby Eva   Bylund Johan   Afzelius Lovisa  

Xenobiotica, Vol. 42, Iss. 9, 2012-09 ,pp. : 841-853

Informa Healthcare

Access to resources Recommend Favorite

Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability

By Howgate E. M.   Rowland Yeo K.   Proctor N. J.   Tucker G. T.   Rostami-Hodjegan A.  

Xenobiotica, Vol. 36, Iss. 6, 2006-06 ,pp. : 473-497

Informa Healthcare

Access to resources Recommend Favorite

Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences

By Inoue† S.   Howgate E. M.   Rowland-Yeo K.   Shimada T.   Yamazaki H.   Tucker G. T.   Rostami-Hodjegan A.  

Xenobiotica, Vol. 36, Iss. 6, 2006-06 ,pp. : 499-513

Informa Healthcare

Access to resources Recommend Favorite