Author: Sakkas Denny Seli Emre Manicardi Gian Carlo Nijs Martine Ombelet William Bizzaro Davide
Publisher: Informa Healthcare
ISSN: 1464-7273
Source: Human Fertility, Vol.7, Iss.2, 2004-06, pp. : 99-103
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
With the successful use of Assisted Reproduction, in particular intracytoplasmic sperm injection (ICSI), to treat infertile couples we have become less discriminating with the quality of spermatozoa we use to treat our patients. Numerous studies have shown the presence of nuclear DNA strand breaks in human ejaculated spermatozoa. The reason why human spermatozoa, in particular from men with abnormal semen parameters, possess these abnormalities in their nuclear DNA is still not clear. Two processes that have been linked to the presence of nuclear DNA strand breaks in spermatozoa are anomalies in apoptosis during spermatogenesis or problems in the packaging of the chromatin during spermiogenesis. Understanding the mechanisms responsible for producing abnormal spermatozoa in the human will improve our knowledge about certain causes of male infertility. More importantly, the impact of such sperm, if selected to perform ICSI, needs to be better understood so that any detrimental paternal effects can be avoided.
Related content
By Kahraman Semra Tasdemir Murat Tasdemir Işlk Vicdan Kubilay Özgür Suat
Human Reproduction, Vol. 11, Iss. 6, 1996-06 ,pp. :
Apoptosis and necrosis in human ejaculated spermatozoa
Human Reproduction, Vol. 19, Iss. 3, 2004-03 ,pp. :
Large nuclear vacuoles are indicative of abnormal chromatin packaging in human spermatozoa
By Franco Jr J. G. Mauri A. L. Petersen C. G. Massaro F. C. Silva L. F. I. Felipe V. Cavagna M. Pontes A. Baruffi R. L. R. Oliveira J. B. A. Vagnini L. D.
International Journal of Andrology, Vol. 35, Iss. 1, 2012-02 ,pp. :