Substitution of the 2′-Hydroxyl Group at Position 2.1 by an Amino Group Interferes with Mg²⁺ Binding and Efficient Cleavage by Hammerhead Ribozyme

By Sioud M.   Leirdal M.  

Biochemical and Biophysical Research Communications, Vol. 262, Iss. 2, 1999-08 ,pp. : 461-466

Elsevier

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A Minimised Hammerhead Ribozyme with Activity against Interleukin-2 in Human Cells

By Sioud M.   Opstad A.   Hendry P.   Lockett T.J.   Jennings P.A.   McCall M.J.  

Biochemical and Biophysical Research Communications, Vol. 231, Iss. 2, 1997-02 ,pp. : 397-402

Elsevier

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Zinc‐dependent cleavage in the catalytic core of the hammerhead ribozyme: evidence for a pH‐dependent conformational change

By Borda Emily J.   Markley John C.   Sigurdsson Snorri Th.  

Nucleic Acids Research, Vol. 31, Iss. 10, 2003-05 ,pp. : 2595-2600

Oxford University Press

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Synthesis and Studies on the Effect of 2-Thiouridine and 4-Thiouridine on Sugar Conformation and RNA Duplex Stability

By Kumar Raju K.   Davis Darrell R.  

Nucleic Acids Research, Vol. 25, Iss. 6, 1997-01 ,pp. : 1272-1280

Oxford University Press

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A pH-dependent Conformational Change, Rather than the Chemical Step, Appears to be Rate-limiting in the Hammerhead Ribozyme Cleavage Reaction

By Murray J.B.   Dunham C.M.   Scott W.G.  

Journal of Molecular Biology, Vol. 315, Iss. 2, 2002-01 ,pp. : 121-130

Academic Press

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