A Class-Independent Drug Screen in Forensic Toxicology Using a Photodiode Array Detector

Author: Drummer Olaf H.   Kotsos Alex   McIntyre Iain M.  

Publisher: Oxford University Press

ISSN: 0146-4760

Source: Journal of Analytical Toxicology, Vol.17, Iss.4, 1993-07, pp. : 225-229

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Abstract

A class-independent drug screen, that is suitable for use in clinical and forensic toxicology and uses gradient-elution high-performance liquid chromatography and photodiode array detection, is presented. The assay is capable of detecting and identifying therapeutic and toxic amounts of barbiturates, anti-convulsants, diuretics, non-steroidal anti-inflammatory drugs, sulfonylurea anti-diabetic drugs, theophylline, and analgesic drugs. The assay has been successfully used to screen over 1000 postmortem blood specimens.