Alternative Splicing of Interleukin-6 mRNA in Mice

Author: Yatsenko O. P.   Filipenko M. L.   Khrapov E. A.   Voronina E. N.   Sennikov S. V.   Kozlov V. A.  

Publisher: Springer Publishing Company

ISSN: 0007-4888

Source: Bulletin of Experimental Biology and Medicine, Vol.138, Iss.1, 2004-07, pp. : 73-76

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Expression of mRNA for interleukin-6, interleukin-6∆3, and interleukin-6∆5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.