In Vitro Genotoxic and Cytotoxic Effects of Protein Somatic Products from Helminths on Donor Blood Lymphocytes

Author： Bekish Vl. Ya.   Durnev A. D.  

Publisher： Springer Publishing Company

ISSN： 0007-4888

Source： Bulletin of Experimental Biology and Medicine, Vol.138, Iss.2, 2004-08, pp. : 174-176

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Protein somatic products of adult helminths Hymenolepis nana and Toxocara canis and secretory-excretory somatic product of Trichinella spiralis larvae In Vitro produced genotoxic and cytotoxic effects on donor blood lymphocytes, which manifested in accumulation of single-chain breaks, alkaline-labile sites in nuclear DNA, and apoptotic cells. This effect depended on the concentration of parasitic protein products during coculturing.

Related content

Effects of doxorubicin on human dental pulp cells in vitro

By Jones T.   Henderson J.   Johnson R.  

Cell Biology and Toxicology, Vol. 21, Iss. 5-6, 2005-09 ,pp. : 207-214 (8)

Springer Publishing Company

Access to resources Recommend Favorite

Effects of Photodynamic Exposure on Endothelial Cells In Vitro

By Andreeva E.   Udartseva O.   Vozovikov I.   Kuzmin S.   Tararak E.  

Bulletin of Experimental Biology and Medicine, Vol. 149, Iss. 2, 2010-08 ,pp. : 262-264 (3)

Springer Publishing Company

Access to resources Recommend Favorite

In Vitro Effects of Pentifin on Some Neurotransmitter Systems in the Brain

By Gorbatova E. N.   Dagaev S. G.   Dolgo-Saburov V. B.   Dukhovich F. S.  

Bulletin of Experimental Biology and Medicine, Vol. 136, Iss. 2, 2003-08 ,pp. : 174-175 (2)

Springer Publishing Company

Access to resources Recommend Favorite

Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells

By Olatunde Farombi E.   Møller P.   Dragsted L.O.  

Cell Biology and Toxicology, Vol. 20, Iss. 2, 2004-03 ,pp. : 71-82 (12)

Springer Publishing Company

Access to resources Recommend Favorite

Cytotoxic potency of trialkyltins to C6 glioma cells in vitro: impact of exposure conditions

By Seibert H.   Mörchel S.   Gülden M.  

Cell Biology and Toxicology, Vol. 20, Iss. 5, 2004-09 ,pp. : 273-283 (11)

Springer Publishing Company

Access to resources Recommend Favorite