Effects of taurine, carnosine, and casomorphine on functional activity of rat peritoneal mast cells

Author： Akhalaya M.   Baizhumanov A.   Graevskaya E.  

Publisher： Springer Publishing Company

ISSN： 0007-4888

Source： Bulletin of Experimental Biology and Medicine, Vol.141, Iss.3, 2006-03, pp. : 328-330

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Abstract

We studied the effects of taurine, carnosine, and casomorphine on histamine release from rat peritoneal mast cells induced by compound 48/80 and ionophore A23187. Differences were revealed in the effect of the test preparations. Taurine inhibited histamine release induced by ionophore A23187, but not by compound 48/80. Carnosine abolished the stimulatory effect of compound 48/80 on histamine release, but did not modulate the effect of ionophore A23187. Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed.

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