Effect of activated protein C on secretory activity of rat peritoneal mast cells

Author： Makarova A.   Rusanova A.   Gorbacheva L.   Umarova B.   Strukova S.  

Publisher： Springer Publishing Company

ISSN： 0007-4888

Source： Bulletin of Experimental Biology and Medicine, Vol.142, Iss.4, 2006-10, pp. : 403-405

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Abstract

Generation of thrombin and activated protein C in the inflammatory focus was demonstrated in rats with experimental acute peritonitis. The contents of thrombin and activated protein C peaked by the 30th and 120th minute of inflammation, respectively. In vitro study showed a decrease in spontaneous and compound 48/80-induced secretion of β-hexosaminidase by peritoneal mast cells under the influence of activated protein C in low concentrations. The antiinflammatory effect of protein C in the focus of acute peritonitis is probably realized through NO release from peritoneal mast cells. This conclusion is derived from the data that L-NAME abolishes the protective effect of activated protein C.

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