Publisher： Bentham Science Publishers
E-ISSN： 1875-6662|10|2|113-120
ISSN： 1573-4080
Source： Current Enzyme Inhibition, Vol.10, Iss.2, 2014-09, pp. : 113-120
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Lipase inhibitors have a high pharmacological interest because they could help in the therapy of diseases in which lipases play an important role such as obesity. Extracts from two Algerian spontaneous plants: Oudneya africana and Pulicaria crispa, were screened for potential lipase inhibitory activity. The enzymatic inhibition produced by these plants extracts is described here for the first time. Additionally, the antioxidant activity of extracts was investigated using 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities, 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activities and phosphomolybdenum complex. The results have shown that ethyl acetate fraction of Pulicaria crispa extract obtained by 70% (v/v) aqueous acetone was the best extract based on its lipase inhibitory activity (IC50 1.33±0.03mg/ml). The extracts of Oudneya africana and Pulicaria crispa showed a pronounced scavenging activity on DPPH, ABTS radicals and had a potent reductive ability on phosphomolybdate assay.
Related content
Access to resources
Recommend
