L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

Publisher: Bentham Science Publishers

ISSN: 2213-3372

Source: Current Organocatalysis, Vol.2, Iss.1, 2015-04, pp. : 44-50

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Abstract

L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

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