Author： Zissis Konstantinos D. Brereton Richard G. Escott Richard
Publisher： R S C Publications
ISSN： 0003-2654
Source： The Analyst, Vol.1997, Iss.10, 1997-10, pp. : 1007-1013
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Abstract
The chromatogram of ropinirole in the presence of about 5% of a closely eluting impurity, obtained by HPLC with diode-array detection, was analysed by chemometric procedures. Log eigenvalue plots were used to determine the relative composition of regions of the chromatogram. It is shown that since the peaks exhibit tailing, unusual behaviour is found in the plots. This is verified by performing simulations, in which it is demonstrated that peak asymmetry has a pronounced influence on this chemometric approach. In many cases of liquid chromatographic analysis, asymmetric peak shapes are encountered and methods for peak purity assessment should be re-evaluated in the light of these asymmetries.
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