Effects of dietary lipoic acid on plasma lipid, in vivo insulin sensitivity, metabolic response to corticosterone and in vitro lipolysis in broiler chickens

Publisher： Cambridge University Press

E-ISSN： 1475-2662|95|6|1094-1101

ISSN： 0007-1145

Source： British Journal of Nutrition, Vol.95, Iss.6, 2006-06, pp. : 1094-1101

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Abstract

The present study consisted of two experiments. The first experiment was conducted to determine the effects of lipoic acid (ALA; 200mg/kg) on plasma lipids and insulin sensitivity of whole-body tissue in broilers treated with or without corticosterone (5mg/kg). Chickens received these agents from 2 to 5 weeks of age in a 2×2 factorial arrangement. Thereafter, from 39 to 42d of age, insulin sensitivity was estimated using the euglycaemic and hyperinsulinaemic clamp technique. Experiment 2 examined whether ALA supplementation for 5 weeks (400mg/kg) would alter short-chain acyl-CoA concentration in the liver and in vitro lipolysis of an adipose tissue slice, in relation to noradrenaline (10μm) supplementation. In experiment 1, ALA had no effect on the corticosterone-induced negative growth performance. ALA lowered plasma glucose level (P<0·05) and, in contrast, increased triacylglycerol level (P<0·05). These responses to ALA had, however, no interrelationship with corticosterone. The rate of glucose uptake of whole-body P<0·05) but was not affected by noradrenaline supplementation. This study suggests that ALA stimulates the insulin sensitivity of tissues regardless of corticosterone-dependent metabolism and that the ALA-induced fatty acid metabolism of broilers differs between the liver and adipose tissue.