Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity

Author： Ignat (Grozav) Adriana   Gaina Luiza   Kuete Victor   Silaghi-Dumitrescu Luminita   Efferth Thomas   Zaharia Valentin  

Publisher： MDPI

E-ISSN： 1420-3049|18|4|4679-4688

ISSN： 1420-3049

Source： Molecules, Vol.18, Iss.4, 2013-04, pp. : 4679-4688

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).

Related content

Microwave-Assisted Synthesis of Phenothiazine and Quinoline Derivatives

By Găină Luiza   Cristea Castelia   Moldovan Claudia   Porumb Dan   Surducan Emanoil   Deleanu Călin   Mahamoud Abdalah   Barbe Jacques   Silberg Ioan A.  

International Journal of Molecular Sciences, Vol. 8, Iss. 2, 2007-02 ,pp. : 70-80 (11)

MDPI

Access to resources Recommend Favorite

Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment

By El Azab Islam H.   Youssef Mohamed M.   Amin Mahmoud A.  

Molecules, Vol. 19, Iss. 12, 2014-11 ,pp. : 19648-19664 (17)

MDPI

Access to resources Recommend Favorite

Microwave Assisted Synthesis of Some New Thiazolopyrimidine, Thiazolodipyrimidine and Thiazolopyrimidothiazolopyrimidine Derivatives with Potential Antioxidant and Antimicrobial Activity

By Youssef Mohamed M.   Amin Mahmoud A.  

Molecules, Vol. 17, Iss. 8, 2012-08 ,pp. : 9652-9667 (16)

MDPI

Access to resources Recommend Favorite

Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification

By Bao Kai   Zhang Weige   Zhang Chuanliang   Qu Yingwei   Tian Liang   Wu Lan   Zhao Xiang   Cheng Maosheng  

Molecules, Vol. 12, Iss. 9, 2007-08 ,pp. : 2123-2129 (7)

MDPI

Access to resources Recommend Favorite

Correction: El Azab, I.H., et al. Microwave-Assisted Synthesis of Novel 2H-Chromene Derivatives Bearing Phenylthiazolidinones and Their Biological Activity Assessment. Molecules 2014, 19, 19648-19664

By El Azab Islam H.   Youssef Mohamed M.   Amin Amin M.  

Molecules, Vol. 20, Iss. 2, 2015-02 ,pp. : 2835-2836 (2)

MDPI

Access to resources Recommend Favorite