A Facile and Efficient Synthesis of Diaryl Amines or Ethers under Microwave Irradiation at Presence of KF/Al2O3 without Solvent and Their Anti-Fungal Biological Activities against Six Phytopathogens

Author： Huang Liang-Zhu   Han Pan   Li You-Qiang   Xu Ying-Meng   Zhang Tao   Du Zhen-Ting  

Publisher： MDPI

E-ISSN： 1422-0067|14|9|18850-18860

ISSN： 1422-0067

Source： International Journal of Molecular Sciences, Vol.14, Iss.9, 2013-09, pp. : 18850-18860

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Abstract

A series of diaryl amines, ethers and thioethers were synthesized under microwave irradiation efficiently at presence of KF/Al2O3 in 83%–96% yields without any solvent. The salient characters of this method lie in short reaction time, high yields, general applicability to substrates and simple workup procedure. At the same time, their antifungal biological activities against six phytopathogen were evaluated. Most of the compounds (3b, 3c, 3g–o) are more potent than thiophannate-methyl against to Magnaporthe oryzae. This implies that diaryl amine or ether moiety may be helpful in finding a fungicide against Magnaporthe oryzae.

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