New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities

Author： Mao Xu-Dong   Chou Gui-Xin   Zhao Sen-Miao   Zhang Cheng-Gang  

Publisher： MDPI

E-ISSN： 1420-3049|21|12|1749-1749

ISSN： 1420-3049

Source： Molecules, Vol.21, Iss.12, 2016-12, pp. : 1749-1749

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Abstract

In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1–5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6–11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds, 4–8 and 10 exhibited potent inhibition of α-glucosidase.

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