

Publisher: John Wiley & Sons Inc
E-ISSN: 2192-6549|62|9|751-755
ISSN: 0009-4536
Source: JOURNAL OF THE CHINESE CHEMICAL SOCIETY (ELECTRONIC), Vol.62, Iss.9, 2015-09, pp. : 751-755
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
AbstractMethanol extract of Alafia barteri leaves showed cytotoxic activity on leukaemia carcinoma K562, and hepatic liver cancer cells WRL (IC50 values 193.1 and 225.0 μM respectively). Isolation of the extract gave ursane triterpenoid, 28‐acety‐urs‐5,20‐dien‐2β,3β,24α‐triol, 1, together with undecanol, 2, stigmasterol, 3 and octadecanoic acid, 4. The structures of these compounds were identified by spectroscopic analysis, including MS, 1D and 2D NMR, and supported with literature data. Compound 1 exhibited cytotoxic activity against K‐562 at 50 and 100 μM concentrations with IC50 74.22 μM, while compounds 2, 3 and 4 showed low inhibition of WRL, MCF‐7 and COLO cell lines.
Related content








Chemical constituents from the leaves of Michelia alba
By Wang Hui-Min
Natural Product Research, Vol. 24, Iss. 5, 2010-03 ,pp. :


By Ma Fenghua Onoda Toshihisa Li Wei Sasaki Tatsunori Ma Ling Zhang Qingbo Koike Kazuo
Natural Product Research, Vol. 27, Iss. 23, 2013-12 ,pp. :