Chemical Constituents from Alafia Barteri Oliv. Leaves with Cytotoxic Activity

E-ISSN： 2192-6549|62|9|751-755

ISSN： 0009-4536

Source： JOURNAL OF THE CHINESE CHEMICAL SOCIETY (ELECTRONIC), Vol.62, Iss.9, 2015-09, pp. : 751-755

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Abstract

AbstractMethanol extract of Alafia barteri leaves showed cytotoxic activity on leukaemia carcinoma K562, and hepatic liver cancer cells WRL (IC50 values 193.1 and 225.0 μM respectively). Isolation of the extract gave ursane triterpenoid, 28‐acety‐urs‐5,20‐dien‐2β,3β,24α‐triol, 1, together with undecanol, 2, stigmasterol, 3 and octadecanoic acid, 4. The structures of these compounds were identified by spectroscopic analysis, including MS, 1D and 2D NMR, and supported with literature data. Compound 1 exhibited cytotoxic activity against K‐562 at 50 and 100 μM concentrations with IC50 74.22 μM, while compounds 2, 3 and 4 showed low inhibition of WRL, MCF‐7 and COLO cell lines.