The synthesis and screening of the antimicrobial activity of some novel 3-(furan-2-yl)-1-(aryl)-3-(phenylthio) propan-1-one derivatives

Author： Ceylan Mustafa  

Publisher： Springer Publishing Company

ISSN： 1054-2523

Source： Medicinal Chemistry Research, Vol.20, Iss.1, 2011-01, pp. : 109-115

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Abstract

A series of thiophenol adducts (3a-m) were prepared by addition of thiophenol to chalcones (1a-m) in the presence of a catalytic amount of KOt-Bu in solvent free conditions. In addition, the antibacterial and antifungal in vitro properties were tested against some human pathogenic microorganisms by employing the disk diffusion technique. A majority of compounds were remarkably active against several of the microorganisms. Compound 3i was determined to be the most active compound.

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