Synthesis of novel 3-chloro-1-(5H-dibenz[b,f]azepine-5yl)propan-1-one derivatives with antioxidant activity

Author： Kumar H.  

Publisher： Springer Publishing Company

ISSN： 1054-2523

Source： Medicinal Chemistry Research, Vol.20, Iss.1, 2011-01, pp. : 101-108

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

A series of 3-chloro-1-(5H-dibenz[b,f]azepine-5yl)propan-1-one derivatives (2a-k) bearing different amino acids were synthesized by base condensation reaction. 3-Chloro-1-(5H-dibenz[b,f]azepine-5yl)propan-1-one(2) was obtained by N-acylation of 5H-dibenz[b,f]azepine (1). All the synthesized compounds were evaluated for their potential over antioxidant activities against inhibition of lipid peroxidation by β-carotene and linoleic acid assay and inhibition of human low-density lipoprotein (LDL) oxidation assay. Typically, compound 2 showed weak antioxidant activity, whereas coupling of different amino acids enhances the antioxidant activities based on the presence of different functional groups. Among the derivatives, compound 2d showed significant antioxidant activities followed by 2h, 2i, 2j and 2k.

Related content

The synthesis and screening of the antimicrobial activity of some novel 3-(furan-2-yl)-1-(aryl)-3-(phenylthio) propan-1-one derivatives

By Ceylan Mustafa  

Medicinal Chemistry Research, Vol. 20, Iss. 1, 2011-01 ,pp. : 109-115 (7)

Springer Publishing Company

Access to resources Recommend Favorite

Practical Synthesis of 1‐(2‐Nitro‐1H‐imidazol‐1‐yl)‐3‐(tosyloxy)propan‐2‐yl acetate for the Radiosynthesis of [18F]‐FMISO

By  

BULLETIN OF THE KOREAN CHEMICAL SOCIETY (ELECTRONIC), Vol. 36, Iss. 2, 2015-02 ,pp. : 559-563 (5)

John Wiley & Sons Inc

Access to resources Recommend Favorite

Synthesis, antimicrobial, analgesic activity, and molecular docking studies of novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde derivatives

By Jayanna N.   Vagdevi H.   Dharshan J.   Raghavendra R.   Telkar Sandeep  

Medicinal Chemistry Research, Vol. 22, Iss. 12, 2013-12 ,pp. : 5814-5822 (9)

Springer Publishing Company

Access to resources Recommend Favorite

Novel N‐Substituted ((1H‐indol‐3‐yl)methylene)benzohydrazides and ((1H‐indol‐3‐yl)methylene)‐2‐phenylhydrazines: Synthesis and Antiplatelet Aggregation Activity

By  

BULLETIN OF THE KOREAN CHEMICAL SOCIETY (ELECTRONIC), Vol. 36, Iss. 11, 2015-11 ,pp. : 2632-2639 (8)

John Wiley & Sons Inc

Access to resources Recommend Favorite

Synthesis, evaluation of antimicrobial activity, and molecular modeling of novel 2-((4-(2H-benzo[d] [1,2,3] triazol-2-yl)piperidin-1-yl)methyl)-5-substituted phenyl-1,3,4-oxadiazoles

By Vankadari Srinivas   Mandala Devender   Pochampalli Jalapathi   Tigulla Parthasarathy   Valeru Anil   Thampu Rajakomuraiah  

Medicinal Chemistry Research, Vol. 22, Iss. 12, 2013-12 ,pp. : 5912-5919 (8)

Springer Publishing Company

Access to resources Recommend Favorite