Author： Bhal P.S.
Publisher： Oxford University Press
ISSN： 1460-2350
Source： Human Reproduction, Vol.16, Iss.8, 2001-08, pp. : 1682-1689
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
BACKGROUND: The aim of the present study was to assess any potential relationship between perifollicular vascularity and outcome in an in-vivo environment following human chorionic gonadotrophin (HCG) administration. METHODS: A total of 182 unselected consecutive patients undergoing stimulated intrauterine insemination (IUI) cycles was recruited where the perifollicular vascularity of follicles ≥16 mm was studied using a subjective grading system and transvaginal power Doppler ultrasonography, 36 h after HCG administration. RESULTS: A total of 601 follicles was studied. The incidence of follicles showing high-grade perifollicular vascularity (3 and 4) was higher than those with low-grade vascularity (1 and 2) (80 versus 20%). Treatment cycles were divided according to uniformity of vascularity grades of follicles ≥16 mm on the day of IUI [55% all high (3/4) grade; 33% mixed (1/2 and 3/4) and 12% all low (1/2) grade]. The mean age and duration of subfertility were significantly higher (P < 0.05),="" whereas="" the="" number="" of="" follicles="" ≥16="" mm="" pre/post="" hcg,="" serum="" oestradiol="" and="" incidence="" of="" ultrashort="" gonadotrophin-releasing="" hormone="" (gnrh)="" agonist="" use="" were="" all="" significantly="" lower="">P < 0.05)="" in="" treatment="" cycles="" with="" uniformly="" low="" follicular="" vascularity="" grades="" compared="" with="" mixed="" or="" uniformly="" high-grade="" cycles.="" however,="" on="" subjecting="" the="" data="" to="" multiple="" logistic="" regression="" analysis,="" the="" only="" independent="" variables="" that="" affected="" pregnancy="" rates="" appeared="" to="" be="" serum="" oestradiol="" (or="" 1.28,="" 1.01–1.62)="" and="" high-grade="" follicular="" vascularity="" (or="" 2.41,="" 1.08–5.40).="" conclusion:="" these="" data="" would="" suggest="" that="" perifollicular="" vascularity="" has="" an="" important="" role="" to="" play="" in="" the="" outcome="" of="" iui="" cycles,="" and="" that="" power="" doppler="" has="" the="" potential="" to="" refine="" the="" management="" of="" assisted="" reproduction="" treatment="" cycles.="">
Related content
Access to resources
Recommend
Human Reproduction, Vol. 22, Iss. 1, 2007-01 ,pp. :