Reproductive semi‐cloning respecting biparental origin

Author: Tateno H.  

Publisher: Oxford University Press

ISSN: 1460-2350

Source: Human Reproduction, Vol.18, Iss.3, 2003-03, pp. : 472-473

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

The original debate article proposed the use of ‘semi‐cloning’ as a viable method for assisted reproduction. This debate counters the proposal as being biologically unsound. Given the fundamental limitations of chromosomal segregation and genomic imprinting, the notion of using the MII oocyte to drive haploidization of a somatic cell genome and thereby obtain a substitute for authentic gametes is ill‐conceived and untenable.