Additive-Free Chemoselective Acylation of Amines

Author: Temperini Andrea   Terlizzi Raffaella   Testaferri Lorenzo   Tiecco Marcello  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.40, Iss.2, 2010-01, pp. : 295-302

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Abstract

Aliphatic and aromatic amines are efficiently acylated by acetic, pivalic, benzoic, phthalic, or maleic anhydrides in ethyl acetate at room temperature. Under the same experimental conditions, amino alcohols are chemoselectively acylated at the amino group.