Author： Rong Liangce Gao Lijiu Han Hongxia Jiang Hong Dai Yisi Tu Shujiang
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.40, Iss.2, 2010-01, pp. : 289-294
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Abstract
A series of 6-amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitriles were prepared in good yields under solvent-free conditions by multicomponent reactions of aromatic aldehyde, malononitrile, and 1-methylpiperidin-4-one in the presence of sodium hydroxide (NaOH). The structures of the products were characterized by infrared, 1H NMR spectra, elemental analysis, and high-resolution mass spectrometery (HRMS).
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