The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

By Fenner Katherine S.   Jones Hannah M.   Ullah Mohammed   Kempshall Sarah   Dickins Maurice   Lai Yurong   Morgan Paul   Barton Hugh A.  

Xenobiotica, Vol. 42, Iss. 1, 2012-01 ,pp. : 28-45

Informa Healthcare

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The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin

By Hiroki Tomoko   Song Young-Han   Liebhaber Stephen A.   Cooke Nancy E.  

Nucleic Acids Research, Vol. 34, Iss. 8, 2006-01 ,pp. : 2154-2165

Oxford University Press

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Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding

By Emoto C.   Murayama N.   Rostami-Hodjegan A.   Yamazaki H.  

Xenobiotica, Vol. 39, Iss. 3, 2009-03 ,pp. : 227-235

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Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds

By Huang Liyue   Chen April   Roberts John   Janosky Brett   Be Xuhai   Berry Loren   Lin Min-Hwa Jasmine  

Xenobiotica, Vol. 42, Iss. 9, 2012-09 ,pp. : 830-840

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Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect

By Li Ling   Nouraldeen Amr   Wilson Alan G. E.  

Xenobiotica, Vol. 43, Iss. 3, 2013-03 ,pp. : 253-262

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