Author： Freeman R. D. Hammaker R. M. Meloan C. E. Fateley W. G.
Publisher： Society for Applied Spectroscopy
ISSN： 0003-7028
Source： Applied Spectroscopy, Vol.42, Iss.3, 1988-03, pp. : 456-460
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Abstract
A successful interface between a high-performance liquid chromatograph and a Raman spectrometer is described. Surface-enhanced techniques are utilized to overcome the sensitivity problem inherent to conventional Raman spectrometry by adding a Ag sol to the chromatographic effluent in a post-column mixing coil. The system is designed so that Raman spectra may be obtained from chromatographic effluent or from flow injection analysis effluent. A common organic dye (pararosaniline hydrochloride) is used to evaluate the reproducibility, dynamic range, and analytical capabilities of the system. The SERS instrument is found to be a viable detector for HPLC and FIA, capable of providing structural information with a sensitivity comparable to that of other commonly used HPLC detectors.
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